- 作者：Shihao Chen ; MD ; OD ; MSc ; Tommy C.Y. Chan ; FRCS ; Jia Zhang ; MD ; MSc ; Ping Ding ; MD ; Jason C.K. Chan ; MB BS ; Marco C.Y. Yu ; PhD ; Yini Li ; MD ; PhD ; Vishal Jhanji ; MD ; FRCOphth ; vishaljhanji@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Qinmei Wang ; MD
- 刊名：Journal of Cataract & Refractive Surgery
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：42
- 期：5
- 页码：738-749
- 全文大小：291 K
Setting
School of Ophthalmology and Optometry and Eye Hospital of Wenzhou Medical College, Wenzhou, China.
Design
Prospective case series.
Methods
Patients with bilateral progressive keratoconus had tetracaine-enhanced epithelium-on CXL. The worse eye had CXL, and the fellow eye was not treated. Results were reported 1, 3, 6, and 12 months postoperatively. The outcomes were compared with those in the fellow untreated eyes.
Results
Twenty-one eyes of 21 patients with a median age of 20.4 years (interquartile range [IQR], 9.5 years) were treated. A significant improvement in postoperative uncorrected distance visual acuity was observed at 12 months (P = .002). Postoperative corrected distance visual acuity improved at 6 months and 12 months (P ≤ .009) compared with baseline values. The maximum K decreased by 1.63 D from the median preoperative maximum K of 62.7 D (IQR, 12.9 D) at 12 months (P < .001). The reduction in maximum K was higher after CXL than in untreated eyes at the end of 12 months (P = .001). Correlation analysis between the preoperative maximum K values and the change over 6 to 12 months between different studies showed a significant correlation (r = −0.764, P < .001; Spearman correlation).
Conclusions
Epithelium-on CXL was an effective treatment for patients with advanced keratoconus. A higher preoperative maximum K value correlated with greater corneal flattening after CXL.
Financial Disclosure
None of the authors has a financial or proprietary interest in any material or method mentioned.