ErbB4 Gene Polymorphism Is Associated With the Risk and Prognosis of Congestive Heart Failure in a Northern Han Chinese Population
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- 作者：Yunhong Wang ; MM ; Yuhui Zhang ; MD ; yuhuizhangjoy@163.com" class="auth_mail" title="E-mail the corresponding author ; Tao An ; MD ; Rongcheng Zhang ; MD ; Xuemei Zhao ; MB ; Nini Liu ; MB ; Shijie Yin ; MM ; Tianyi Gan ; MD ; Tuo Liang ; MM ; Yan Huang ; MM ; Qiong Zhou ; MB ; Jian Zhang ; MD ; PhD ; fwzhangjian62@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ErbB4 ; polymorphism ; heart failure
- 刊名：Journal of Cardiac Failure
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：22
- 期：9
- 页码：700-709
- 全文大小：511 K
文摘
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A case-control study evaluated the association between Neuregulin-1/ErbB2/ErbB4 gene polymorphisms and heart failure in the Northern Han Chinese population.
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Variants of 4 SNPs in the ErbB4 gene were associated with the risk of heart failure.
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The T variant of rs13003941 was associated with LV enlargement and increased risk of overall and CV death.
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Neuregulin-1/ErbB2 gene polymorphisms were not associated with heart failure risk or prognosis.