Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis

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• 作者：Zefeng Yang ; Yong Zhou ; Xuefeng Wang ; Shiliang Gu ; Jianmin Yu ; Guohua Liang ; Changjie Yan ; Chenwu Xu
• 关键词：Tubby-like protein gene family ; Species-specific expansion ; Segmental duplication ; Co-evolution
• 刊名：Genomics
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：92
• 期：4
• 页码：246-253
• 全文大小：707 K

文摘

Tubby-like proteins, which are characterized by a highly conserved tubby domain, play an important role in the maintenance and function of neuronal cells during postdifferentiation and development in mammals. In additional to the tubby domain, most tubby-like proteins in plants also possess an F-box domain. Plants also appear to harbor a large number of TLP genes. To gain insight into how TLP genes evolved in plants, we conducted a comparative phylogenetic and molecular evolutionary analysis of the tubby-like protein gene family in Arabidopsis, rice, and poplar. Genomewide screening identified 11 TLP genes in Arabidopsis, 14 in rice, and 11 in poplar. Phylogenetic trees, domain organizations, and intron/exon structures classified this family into three subfamilies and indicated that species-specific expansion contributed to the evolution of this family in plants. We determined that in rice and poplar, the tubby-like protein family had expanded mainly through segmental duplication events. Tissue-specific expression analysis indicated that functional diversification of the duplicated TLP genes was a major feature of long-term evolution. Our results also demonstrated that the tubby and F-box domains had co-evolved during the evolution of proteins containing both domains.