Left Ventricular Hypertrophy Causes Different Changes in Longitudinal, Radial, and Circumferential Mechanics in Patients with Hypertension: A Two-Dimensional Speckle Tracking Study

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• 作者：Hidemichi Kouzu ; MD ; PhD^a ; ^{kouzu@sapmed.ac.jp} ; Satoshi Yuda ; MD ; PhD^b ; Atsuko Muranaka ; MD ; PhD^a ; Takahiro Doi ; MD^a ; Hitomi Yamamoto ; MD^a ; Shinya Shimoshige ; MD^a ; Mamoru Hase ; MD ; PhD^c ; Akiyoshi Hashimoto ; MD ; PhD^a ; Shigeyuki Saitoh ; MD ; PhD^a ; Kazufumi Tsuchihashi ; MD ; PhD^a ; Tetsuji Miura ; MD ; PhD^a ; Naoki Watanabe ; MD ; PhD^b ; Kazuaki Shimamoto ; MD ; PhD^a
• 关键词：Hypertension ; Strain ; Two-dimensional speckle-tracking
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：24
• 期：2
• 页码：192-199
• 全文大小：610 K

文摘

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Background

Systolic reserve is an important compensatory mechanism against increasing afterload. Although longitudinal systolic dysfunction with preserved ejection fraction has been reported in hypertensive hearts, radial and circumferential function has not been fully examined. The aim of this study was to investigate three-directional systolic function and its relationships with left ventricular geometry in asymptomatic hypertensive patients using two-dimensional speckle-tracking imaging.

Methods

Echocardiographic evaluations were performed in 74 hypertensive patients and 55 age-matched control subjects.

Results

Longitudinal strain was significantly reduced in the hypertrophy groups compared with that in control subjects (concentric, ?5.1 ¡À 4.0 % ; eccentric, ?5.9 ¡À 4.4 % ; control, ?8.9 ¡À 3.3 % ; P < .05). Conversely, radial strain was significantly higher in the normal geometry group than in control subjects (53.8 ¡À 19.4 % vs 40.3 ¡À 15.1 % , P < .05). However, this augmentation was attenuated in the other geometries.

Conclusion

Hypertrophic remodeling attenuates compensatory augmentation of radial systolic function and is associated with latent longitudinal systolic dysfunction.