Protein complex formation and intranuclear dynamics of NAC1 in cancer cells
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- 作者：Naomi Nakayama
- 关键词：Nucleus accumbens-associated protein 1 (NAC1) ; Protein complex formation ; Intranuclear dynamics ; Live cell photobleaching analysis ; Fluorescence recovery after photobleaching (FRAP) ; Fluorescence loss in photobleaching (FLIP)
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：606
- 期：Complete
- 页码：10-15
- 全文大小：1555 K
文摘
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NAC1 forms a 300–500 kDa protein complex or complexes in cancer cells.
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NAC1 shows significantly slower recovery kinetics than that of freely diffusing GFP.
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NAC1 in the nucleus is associated with or interacts with nuclear proteins or chromatin.
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Dimer formation by NAC1 coincides with significantly slower diffusion in the nucleus.