Frequent deletion of chromosome 3 in malignant sporadic pancreatic endocrine tumors

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• 作者：Guo ; Sydney S. ; Arora ; Charanjit ; Shimoide ; Alan T. ; Sawicki ; Mark P.
• 关键词：Pancreatic endocrine tumors ; Loss of heterozygosity ; Chromosome 3 ; Tumor suppressor ; PET ; pancreatic endocrine tumor ; MEN1 ; multiple endocrine neoplasia ; type-1 ; LOH ; loss of heterozygosity ; SCDR ; smallest common deleted region
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2002
• 出版时间：April 25, 2002
• 年：2002
• 卷：190
• 期：1-2
• 页码：109-114
• 全文大小：154 K

文摘

Pancreatic endocrine tumors (PETs) arise from neuroendocrine cells in and around the pancreas. As loss of heterozygosity (LOH) of chromosome 3 has been reported in sporadic PETs, we examined 16 sporadic PETs for LOH of 10 polymorphic DNA markers spanning both arms of chromosome 3. LOH was demonstrated in 4 of 8 (50 % ) sporadic PETs with hepatic metastasis, but in none of 8 sporadic PETs without hepatic involvement. The smallest common-deleted region (SCDR) mapped to 3q27-qter. Analysis of this data with the status of markers on chromosomes 1, 11, and MEN1 mutations in these 16 sporadic PETs revealed that chromosome 3q loss may be a late event in sporadic PET tumorigenesis. These data, combined with reports from other investigators, indicate that chromosome 3q27-qter may contain a tumor suppressor gene that's important in the tumorigenesis of sporadic PETs.