Structural Insight into the Mechanism of TFIIH Recognition by the Acidic String of the Nucleotide Excision Repair Factor XPC
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- 作者：Masahiko Okuda1 ; Minoru Kinoshita2 ; 3 ; Erina Kakumu2 ; 3 ; Kaoru Sugasawa2 ; 3 ; Yoshifumi Nishimura1 ; nisimura@tsurumi.yokohama-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2015
- 出版时间：6 October 2015
- 年：2015
- 卷：23
- 期：10
- 页码：1827-1837
- 全文大小：4054 K
文摘
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XPC extensively recognizes the p62 PH domain via an acidic string binding mode
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Human XPC and yeast Rad4 differ in binding to the PH domain and their significance
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XPC, TFIIEα, and p53 target the same basic surface of p62 PH domain in unique modes
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Binding-deficient XPC cells show impaired UV resistance and repair of photoproducts