Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism
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- 作者：Shambaditya Saha1 ; Christoph A. Weber2 ; Marco Nousch3 ; Omar Adame-Arana2 ; Carsten Hoege1 ; Marco Y. Hein4 ; Erin Osborne-Nishimura5 ; Julia Mahamid4 ; Marcus Jahnel1 ; Louise Jawerth1 ; 2 ; Andrej Pozniakovski1 ; Christian R. Eckmann3 ; Frank Jü ; licher2 ; julicher@pks.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Anthony A. Hyman1 ; 6 ; hyman@mpi-cbg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：8 September 2016
- 年：2016
- 卷：166
- 期：6
- 页码：1572-1584.e16
- 全文大小：5584 K
文摘
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The protein PGL-3 can phase separate into P-granule-like droplets in vitro
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Assembly of PGL-3 droplets at physiological concentration requires mRNA binding to PGL-3
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MEX-5 inhibits mRNA-dependent droplet assembly by competing with PGL-3 for binding mRNA
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Competition among MEX-5 and PGL-3 for mRNA can account for P granule segregation in vivo