- 作者：Woo Kyung Kim ; Ji-Won Kwon ; Ju-Hee Seo ; Hyung Young Kim ; Jinho Yu ; Byoung-Ju Kim ; Hyo-Bin Kim ; So Yeon Lee ; Kyung Won Kim ; Mi-Jin Kang ; Yee-Jin Shin ; Soo-Jong Hong
- 关键词：Allergic rhinitis ; prevalence ; risk factor ; IL-13 polymorphism ; gene-environment interaction ; infancy
- 刊名：Journal of Allergy and Clinical Immunology
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：130
- 期：2
- 页码：421-426.e5
- 全文大小：288 K
Background
The prevalence of allergic rhinitis (AR) is increasing worldwide. Allergic diseases develop in susceptible subjects when they are exposed to specific environmental factors.Objective
We analyzed changes in the prevalence of AR and identified genetic and environmental factors in early childhood that affect risk.
Methods
We used the International Study of Asthma and Allergies in Childhood questionnaire to collect data on AR, allergies, and environmental exposures from 4554 elementary school students from 5 areas of Seoul, Korea, in 2008. We also obtained DNA from 1050 subjects from 1 area of Seoul for genotype analysis of IL13.
Results
We identified genetic and environmental factors during infancy and early childhood that increased the risk for current AR (resulting in a diagnosis of AR and AR symptoms in the past 12 months) in elementary school-aged children. These included allergic disease in parents and antibiotic use in infants, allergic disease in parents and exposure of infants to mold, and allergic disease in parents and moving an infant to a newly built house. The risk of current AR also increased in subjects with GA or AA at nucleotide 2044 in IL13 who had been exposed to mold in the home during infancy (adjusted odds ratio, 3.27; 95 % CI, 1.75-6.11) compared with subjects who had GG at this position and had not been exposed to mold (adjusted odds ratio, 3.27; 95 % CI, 1.75-6.11).
Conclusion
The prevalence of AR is increasing in Korean children. Children with a family history of allergic disease and exposure to specific environmental risk factors during infancy are more likely to have AR. Children with GA or AA at IL13(+2044) are at increased risk for AR when exposed to mold in the home during the first year of life.