Reductive amination-assisted quantitation of tamoxifen and its metabolites by liquid phase chromatography tandem mass spectrometry
详细信息 查看全文
- 作者：Shih-Shin Lianga ; b ; liang0615@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Tsu-Nai Wangc ; d ; Chien-Chih Chiua ; Po-Lin Kuoe ; Mei-Fang Huanga ; Meng-Chieh Liua ; Eing-Mei Tsaif ; g ; tsaieing@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tamoxifen ; Reductive amination ; Absolute quantification ; Endoxifen ; N-Desmethyltamoxifen
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：1434
- 期：Complete
- 页码：64-69
- 全文大小：1664 K
文摘
- •
Determination of tamoxifen and its metabolites in human serum.
- •
Development of a simplified modification by reductive amination for the absolute quantification using LC–MS/MS.
- •
Reductive amination using formaldehyde-D2 enhanced MS signal intensities.
- •
Demonstration of the absolute quantification, including tamoxifen and its metabolites, which were derivatized.