Tanshinone IIA affects the HDL subfractions distribution not serum lipid levels: Involving in intake and efflux of cholesterol
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- 作者：Lian-qun Jia ; Ni Zhang ; Ying Xu ; Wen-na Chen ; Mei-lin Zhu ; Nan Song ; Lu Ren ; Hui-min Cao ; Jun-yan Wang ; Guan-lin Yang ; zyzxsys@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tanshinone IIA ; HDL subfractions ; Intake of cholesterol ; Efflux of cholesterol ; SREBP-2
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：592
- 期：Complete
- 页码：50-59
- 全文大小：2404 K
文摘
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Tanshinone IIA reduced the lipid deposition in liver significantly, but it had no influence on the levels of serum lipids.
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Tanshinone IIA influence the HDL subfractions distribution, large subfractions increased while middle subfractions decreased significantly.
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Tanshinone IIA may regulate HDL subfractions distribution and thereby affecting the intake and efflux of cholesterol in the RCT process.