Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
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- 作者：Fengju Chen1 ; 29 ; Yiqun Zhang1 ; 29 ; Yasin Şenbabaoğlu2 ; Giovanni Ciriello3 ; Lixing Yang4 ; Ed Reznik2 ; Brian Shuch5 ; Goran Micevic6 ; 7 ; Guillermo De Velasco8 ; Eve Shinbrot9 ; Michael S. Noble10 ; Yiling Lu11 ; Kyle R. Covington9 ; Liu Xi9 ; Jennifer A. Drummond9 ; Donna Muzny9 ; Hyojin Kang12 ; Junehawk Lee12 ; 13 ; Pheroze Tamboli14 ; Victor Reuter15 ; Carl Simon Shelley16 ; Benny A. Kaipparettu1 ; 17 ; Donald P. Bottaro18 ; Andrew K. Godwin19 ; Richard A. Gibbs9 ; 17 ; Gad Getz10 ; 20 ; Raju Kucherlapati21 ; 22 ; Peter J. Park4 ; Chris Sander2 ; Elizabeth P. Henske10 ; 22 ; Jane H. Zhou23 ; David J. Kwiatkowski10 ; 22 ; Thai H. Ho24 ; Toni K. Choueiri8 ; James J. Hsieh25 ; Rehan Akbani26 ; Gordon B. Mills11 ; A. Ari Hakimi27 ; David A. Wheeler9 ; 17 ; Chad J. Creighton1 ; 9 ; 26 ; 28 ; creighto@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：14
- 期：10
- 页码：2476-2489
- 全文大小：8853 K
文摘
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Comprehensive molecular analysis of 894 primary renal cell carcinomas
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Nine subtypes defined by systematic analysis of five genomic data platforms
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Substantial molecular diversity represented within each major histologic type
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Presumed actionable alterations include PI3K and immune checkpoint pathways