Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation
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- 作者：Marie-Claude Gingras1 ; 2 ; 3 ; mgingras@bcm.edu" class="auth_mail" title="E-mail the corresponding author ; Kyle R. Covington1 ; David K. Chang4 ; 5 ; 6 ; 7 ; Lawrence A. Donehower1 ; 8 ; Anthony J. Gill6 ; 9 ; 10 ; Michael M. Ittmann3 ; 11 ; 12 ; Chad J. Creighton1 ; 3 ; Amber L. Johns6 ; Eve Shinbrot1 ; Ninad Dewal1 ; William E. Fisher2 ; 3 ; 13 ; Australian Pancreatic Cancer Genome Initiative
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：907-919
- 全文大小：3529 K
文摘
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Three periampullary tumor types share a common molecular blueprint
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Frequent WNT pathway disruption can be a potential therapeutic target
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ELF3 is a frequently mutated tumor suppressor gene of periampullary tumors