Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia

详细信息    查看全文

• 作者：Nawin Manachai^a ; Yusuke Saito^a ; Shingo Nakahata^a ; Avinash Govind Bahirvani^b ; Motomi Osato^b ; Kazuhiro Morishita^a ; ^{kmorishi@med.miyazaki-u.ac.jp}
• 关键词：EVI1 ; CML ; Myeloid blast crisis ; LEF1/β-catenin signaling ; p53
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：994-1000
• 全文大小：1926 K
• 卷排序：482

文摘

Transcriptional regulation of EVI1 in CML-BC is proposed. EVI1 transcription is directly regulated by LEF1/β-catenin complex in CML-BC. Loss of p53 function as a key regulator for β-catenin-EVI1 in CML myeloid-BC. The LEF1/β-catenin binding site on the EVI1 promoter is a new target for CML-BC.