Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs
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- 作者：Jiao Yang1 ; 2 ; Renpeng Guo1 ; 2 ; Hua Wang1 ; 2 ; Xiaoying Ye1 ; 2 ; Zhongcheng Zhou1 ; 2 ; Jiameng Dan1 ; 2 ; Haiying Wang1 ; 2 ; Peng Gong1 ; 2 ; Wei Deng1 ; 2 ; Yu Yin1 ; 2 ; ShiQing Mao3 ; Lingbo Wang3 ; Junjun Ding4 ; Jinsong Li3 ; David L. Keefe5 ; Meelad M. Dawlaty6 ; Jianlong Wang4 ; GuoLiang Xu3 ; Lin Liu1 ; 2 ; liulin@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tet ; DNA methylation ; embryonic stem cells ; telomere ; pluripotency ; Dnmt3b ; Zscan4
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：24 May 2016
- 年：2016
- 卷：15
- 期：8
- 页码：1809-1821
- 全文大小：4663 K
文摘
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Tet enzymes maintain telomere length
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Tet enzymes maintain chromosomal stability of ESCs
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Dnmt3b and 5hmC are involved in Tet-signaling-mediated telomere maintenance
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Excessive Zscan4 and Dnmt3b lead to heterogeneous telomere elongation and loss