Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice
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- 作者：Jinhui Wanga ; Shiwei Hua ; b ; hushiweihai@163.com" class="auth_mail" title="E-mail the corresponding author ; Wei Jianga ; b ; Wendong Songa ; Lu Caia ; Jingfeng Wangb
- 关键词：Fucoidan ; Sea cucumber ; Inflammatory response ; Insulin resistance
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：15-23
- 全文大小：1060 K
文摘
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Ib-FUC significantly reduced blood glucose and increases insulin sensitivity.
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Inflammatory response was remarkably mitigated by supplementary Ib-FUC.
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Ib-FUC normalized hepatic HK, PK, GP, and G6Pase, and activated insulin signaling.
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Ib-FUC alleviates inflammation via inactivation of JNK and IKK-β/NFκB pathways.
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Ib-FUC is a novel functional factor for inflammation and insulin resistance.