Development of a UPLC-MS/MS method for the determination of lomefloxacin in rabbit aqueous humor and its application to a pharmacokinetic study
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- 作者：Shiwen Song ; Dongyang Zhao ; Jing Sun ; Qiuyan Miao ; Xiaojie Liu ; Yanling Wang ; Lu Zhong ; Meng Xu ; Peng Zhang ; Ph D ; zhangpengspu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lomefloxacin ; Eye drops ; Rabbit aqueous humor ; UPLC&ndash ; MS/MS ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：187-192
- 全文大小：1367 K
文摘
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A novel UPLC–MS/MS method was developed for the determination of lomefloxacin in rabbit aqueous humor.
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This is the first report of the pharmacokinetics of lomefloxacin using a validated UPLC–MS/MS method.
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The developed method was successfully applied to the pharmacokinetic study of lomefloxacin hydrochloride in rabbit aqueous humor.
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A formulation of lomefloxacin hydrochloride eye drops was designed.