Effect of chronic kidney disease on the healing of titanium implants

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• 作者：Huawei Zou ; Xuefeng Zhao ; Ningyuan Sun ; Shiwen Zhang ; Tadatoshi Sato ; Haiyang Yu ; Qianming Chen ; Hans-Peter Weber ; Michel Dard ; Quan Yuan ; Beate Lanske
• 关键词：Dental implants ; Chronic kidney diseases ; Bone mineralization ; Osseointegration ; Parathyroid hormone (PTH) ; Fibroblast growth factor 23 (FGF23)
• 刊名：Bone
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：56
• 期：2
• 页码：410-415
• 全文大小：1005 K

文摘

Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For in vitro tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.