Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients

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• 作者：Dandan Yan^a ; ¹ ; Jie Wang^a ; ¹ ; Feng Jiang^a ; Rong Zhang^a ; Xue Sun^a ; Tao Wang^a ; Shiyun Wang^a ; Danfeng Peng^a ; Zhen He^a ; Yuqian Bao^a ; Cheng Hu^a ; ^b ; ^{alfredhc@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Weiping Jia^a ; ^{wpjia@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Uric acid ; Diabetic kidney disease ; SLC2A9 ; ABCG2 ; Single nucleotide polymorphisms
• 刊名：Journal of Diabetes and its Complications
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：30
• 期：5
• 页码：798-802
• 全文大小：223 K

文摘

We aimed to investigate the association between uric acid related genetic loci and DKD susceptibility in type 2 diabetes patients.

Methods

Seventeen single nucleotide polymorphisms (SNPs) from thirteen loci related to serum uric acid were genotyped in 2,892 type 2 diabetes patients. Associations between SNPs and uric acid, SNPs and quantitative traits related to DKD or its susceptibility were evaluated.

Results

In this study, uric acid showed a strong association with DKD (OR = 1.006, p < 0.0001). GCKR rs780094, SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142, SLC22A12 rs505802 and NRXN2 rs506338 were positively associated with serum uric acid (p = 3.79E-05, 0.0002, 2.04E-10, 2.23E-09, 0.0018 and 0.0015, respectively). SLC2A9 rs11722228 and SF1 rs606458 were significantly associated with DKD (OR = 0.864, p = 0.0440; OR = 1.223, p = 0.0038). SLC2A9 rs3775948 and ABCG2 rs2231142 were associated with DKD marginally (OR = 0.878, p = 0.0506; OR = 0.879, p = 0.0698). SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 and SF1 rs606458 were significantly associated with the estimated glomerular filtration rate (p = 0.0005, 0.0006, 0.0003, and 0.0424, respectively).

Conclusions

Our study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes.