Pulmonary platelet accumulation induced by catecholamines: Its involvement in lipopolysaccharide-induced anaphylaxis-like shock

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• 作者：Zhiqian Yu^a ; ^b ; ^{yu_zhiqian@med.tohoku.ac.jp} ; Hiroko Saito^c ; Hirotada Otsuka^d ; Yosuke Shikama^a ; ^e ; Hiromi Funayama^a ; ^f ; ^g ; Mai Sakai^b ; Shigeo Murai^c ; Masanori Nakamura^d ; Takashi Yokochi^h ; Haruhiko Takada^f ; Shunji Sugawara^a ; Yasuo Endo^a
• 关键词：ALS ; anaphylaxis-like lethal shock ; Clo-lip ; clodronate-encapsulated liposomes ; HPLC ; high performance liquid chromatography ; 5HT ; 5-hydroxytryptamine ; KO3 ; Klebsiella O3 ; LPS ; lipopolysaccharide ; PBS ; phosphate-buffered saline ; PPA ; pulmonary platelet accumulation ; RS ; rapid shock
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：40-52
• 全文大小：1524 K
• 卷排序：43

文摘

It is already known that LPS stimulates macrophages to release catecholamines (CAs). CAs stimulated platelets and induced pulmonary platelet accumulation (PPA) in mice. In addition, CAs stimulated macrophages to release complement C5 via α2-receptors. Such released C5 may destroy pulmonary platelets and induce rapid shock. These effects may underlie LPS-induced PPA and anaphylaxis-like shock in mice.