A novel approach for prevention of lethal GVHD by selective elimination of alloreactive donor lymphocytes prior to stem cell transplantation

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• 作者：Panigrahi ; Soumya ; Morecki ; Shoshana ; Yacovlev ; Elena ; Gelfand ; Yael ; Kassir ; Judith ; Slavin ; Shimon
• 刊名：Experimental Hematology
• 出版年：2004
• 出版时间：August, 2004
• 年：2004
• 卷：32
• 期：8
• 页码：756-764
• 全文大小：209 K

文摘

Experiments were designed to investigate a new concept aiming for induction of graft-vs-malignancy (GVM) effect prior to stem cell transplantation (SCT). Mismatched lymphocytes given pre-SCT will be followed by a selective elimination of alloreactive donor lymphocytes, thus avoiding lethal graft-vs-host disease (GVHD).