Depletion of alloantigen-primed lymphocytes overcomes resistance to allogeneic bone marrow in mildly conditioned recipients
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- 作者：Prigozhina ; Tatyana B. ; Elkin ; Gregory ; Gurevitch ; Olga ; Morecki ; Shoshana ; Yakovlev ; Elena ; et. al.
- 关键词：Transplantation tolerance ; Bone marrow transplantation ; Reduced-intensity conditioning ; Cyclophosphamide ; APLD (alloantigen-primed lymphocytes depletion)
- 刊名：Blood Cells, Molecules, and Diseases
- 出版年：2004
- 出版时间：November - December, 2004
- 年：2004
- 卷：33
- 期：3
- 页码：238-247
- 全文大小：434 K
文摘
Successful implantation of allogeneic bone marrow (BM) cells after nonmyeloablative conditioning would allow to compensate for the inadequate supply of compatible grafts and to reduce mortality of graft-vs.-host disease (GVHD). Recently, we proposed to facilitate engraftment of mismatched BM by conditioning for alloantigen-primed lymphocyte depletion (APLD) with cyclophosphamide (CY). Here we summarize the experimental results obtained by this approach.