Inhibition of glycogen synthase kinase-3 (GSK3) promotes the neural differentiation of full-term amniotic fluid-derived stem cells towards neural progenitor cells
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- 作者：Liyang Gaoa ; pandarun@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Mingyan Zhaoa ; Wei Yeb ; Jinzhi Huangb ; Jiaqi Chua ; Shouquan Yana ; Chaojun Wangc ; Rong Zengc ; wsgly@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：hAFS ; cellshuman amniotic fluid-derived cells ; hESCs ; human embryonic stem cells ; SVZ ; subventrical zone ; EBs ; embryoid bodies ; CNS ; central nervous system ; iPSCs ; induced pluripotent stem cells ; GSK3 ; Glycogen synthase kinase 3 ; NPCs ; neural precursor/progenitor cells ; ICC ; Immunocytochemistry ; FACS ; fluorescence activated cell sorting
- 刊名：Tissue and Cell
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：48
- 期：4
- 页码：312-320
- 全文大小：2606 K
文摘
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The GSK3 inhibitor SB216763 promotes the self-renewal of CD117-positive hAFS cells.
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The GSK3 inhibitor SB216763 promotes the direct differentiation of CD117-positive hAFS cells towards neural precursor cells.
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This study provides a new protocol for hAFS cells to commit efficiently into a neural fate within a short period of time.