Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein
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- 作者：Shuai Gao1 ; 2 ; 6 ; Yanfei Gao2 ; 3 ; 6 ; Housheng Hansen He4 ; Dong Han1 ; Wanting Han1 ; Amy Avery1 ; Jill A. Macoska1 ; Xiaming Liu5 ; Sen Chen2 ; Fen Ma2 ; Shaoyong Chen2 ; schen@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Steven P. Balk2 ; sbalk@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Changmeng Cai1 ; 2 ; 7 ; changmeng.cai@umb.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：prostate cancer ; androgen receptor ; AR ; androgen deprivation therapy ; transcriptional repression ; DNA replication ; DNA damage repair ; metabolism ; Retinoblastoma protein ; Rb ; E2F1
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：966-976
- 全文大小：3557 K
文摘
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AR directly suppresses DNA replication gene expression by enhancing Rb recruitment
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AR-mediated repression is enhanced in CRPC cells expressing high AR levels
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AR indirectly stimulates DNA replication through Rb hyperphosphorylation
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Blocking CDK4/6 activity can enhance AR-mediated suppression of proliferation