Evaluation of renal allografts function early after transplantation using intravoxel incoherent motion and arterial spin labeling MRI

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• 作者：Tao Ren^a ; ^{abc2008093116@163.com" class="auth_mail" title="E-mail the corresponding author} ; Cheng-Long Wen^a ; ^{jacinthnoel@126.com" class="auth_mail" title="E-mail the corresponding author} ; Li-Hua Chen^a ; ^{li_hos@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shuang-Shuang Xie^a ; ^{happyness0903@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yue Cheng^a ; ^{beautifullove89@126.com" class="auth_mail" title="E-mail the corresponding author} ; Ying-Xin Fu^b ; ^{rainyday800@163.com" class="auth_mail" title="E-mail the corresponding author} ; Niels Oesingmann^c ; ^{mayday0309@126.com" class="auth_mail" title="E-mail the corresponding author} ; Andre de Oliveira^d ; ^{wuyanh_supper2@163.com" class="auth_mail" title="E-mail the corresponding author} ; Pan-Li Zuo^e ; ^{lilusia@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jian-Zhong Yin^a ; ^{springwindy90@126.com" class="auth_mail" title="E-mail the corresponding author} ; Shuang Xia^a ; ^{wangzl_186@126.com" class="auth_mail" title="E-mail the corresponding author} ; Wen Shen^a ; ^{shenwen66happy@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：IVIM ; ASL ; Renal allograft ; Diagnostic efficacy
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：34
• 期：7
• 页码：908-914
• 全文大小：932 K

文摘

To evaluate renal allografts function early after transplantation using intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) MRI.

Methods

This prospective study was approved by the local ethics committee, and written informed consent was obtained from all participants. A total of 82 participants with 62 renal allograft recipients (2–4 weeks after kidney transplantation) and 20 volunteers were enrolled to be scanned using IVIM and ASL MRI on a 3.0 T MR scanner. Recipients were divided into two groups with either normal or impaired function according to the estimated glomerular filtration rate (eGFR) with a threshold of 60 ml/min/1.73 m². The apparent diffusion coefficient (ADC) of pure diffusion (ADC_slow), the ADC of pseudodiffusion (ADC_fast), perfusion fraction (PF), and renal blood flow (RBF) of cortex were compared among three groups. The correlation of ADC_slow, ADC_fast, PF and RBF with eGFR was evaluated. The receiver operating characteristic (ROC) curve and binary logistic regression analyses were performed to assess the diagnostic efficiency of using IVIM and ASL parameters to discriminate allografts with impaired function from normal function. P < 0.05 was considered statistically significant.

Results

In allografts with normal function, no significant difference of mean cortical ADC_slow, ADC_fast, and PF was found compared with healthy controls (P > 0.05). Cortical RBF in allografts with normal function was statistically lower than that of healthy controls (P < 0.001). Mean cortical ADC_slow, ADC_fast, PF and RBF were lower for allografts with impaired function than that with normal function (P < 0.05). Mean cortical ADC_slow, ADC_fast, PF and RBF showed a positive correlation with eGFR (all P < 0.01) for recipients. The combination of IVIM and ASL MRI showed a higher area under the ROC curve (AUC) (0.865) than that of ASL MRI alone (P = 0.02).

Conclusion

Combined IVIM and ASL MRI can better evaluate the diffusion and perfusion properties for allografts early after kidney transplantation.