Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells
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- 作者：Hui Pengb ; c ; 1 ; Huihui Wanga ; 1 ; Peng Xueb ; d ; Yongyong Houa ; Jian Dongb ; e ; Tong Zhoub ; Weidong Qud ; Shuangqing Pengc ; Jin Lif ; Paul L. Carmichaelf ; Bud Nelsonb ; Rebecca Clewellb ; Qiang Zhangb ; Melvin E. Andersenb ; Jingbo Pia ; b ; jpi@mail.cmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NRF2 ; Chemotherapeutic resistance ; Arsenic trioxide ; Leukemia ; Ethionamide ; Isoniazid ; Cytotoxicity
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：292
- 期：Complete
- 页码：1-7
- 全文大小：1143 K
文摘
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Identification of novel inhibitors of ARE-dependent transcription
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Suppression of NRF2–ARE sensitizes THP-1 cells to chemotherapy.
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Ethionamide suppresses ARE-dependent transcriptional activity.
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Ethionamide and isoniazid increase the cytotoxicity of As2O3 in AML cells.
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Sensitization of THP-1 cells to As2O3 toxicity by ethionamide is NRF2-dependent.