Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain
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- 作者：Xiao-Yan Zenga ; Qian Zhangb ; Jing Wangb ; Jing Yub ; Shui-Ping Hanc ; Jun-Yang Wangb ; jywang@mail.xjtu.edu.cn" class="auth_mail
- 关键词：Red nucleus ; Tumor necrosis factor receptor ; Spared nerve injury ; Neuropathic pain
- 刊名：Neuroscience Letters
- 出版年：21 May 2014
- 年：2014
- 卷：569
- 期：Complete
- 页码：43-48
- 全文大小：2117 K
文摘
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Spared nerve injury (SNI) up-regulates TNFR1 and TNFR2 in the red nucleus (RN).
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The up-regulation of TNFR2 in the RN of rats with SNI is earlier than that of TNFR1.
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TNFR1 in the RN plays crucial role in the early and later stages of neuropathic pain.
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TNFR2 in the RN plays an important role in the early stage of neuropathic pain.