The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects

详细信息    查看全文

• 作者：Mei Yang ; Jules Mamy ; Qiang Wang ; Yan-Hui Liao ; Vasish Seewoobudul ; Shui-Yuan Xiao ; Wei Hao
• 关键词：ASPD ; antisocial personality disorder ; bp ; base-pair ; BPD ; borderline personality disorder ; COMT ; catechol-O-methyltransferase gene ; DA ; dopamine ; DAT ; dopamine transporter gene ; 5-HT ; 5-hydroxytryptamine or serotonin ; 5-HTR2A ; 5-hydroxytryptamine receptor 2A gene ; 5-HTT ; 5-hydroxytryptamine transporter gene ; 5-HTTVNTR ; 5-hydroxytryptamine transporter variable number of tandem repeats ; LDR ; ligase detection reaction ; MAOA ; monoamine oxidase A gene ; MAOA-LPR ; monoamine oxidase A gene-linked polym
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：3 April, 2014
• 年：2014
• 卷：50
• 期：Complete
• 页码：74-82
• 全文大小：431 K

文摘

Objective

To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with co-morbid borderline personality disorder (BPD) in female heroin-dependent patients.

Subjects and methods

In a case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 296 female heroin-dependent patients (including 61 patients with BPD and 235 without BPD) and 101 normal females by genotypes, alleles, and interaction between genes.

Results

Female heroin-dependent subjects with BPD have lower frequency of the high activity allele (L: 4 repeats (4R)) of MAOA-LPR than those female heroin-dependent subjects without BPD, and have higher 5-HTTVNTR 10R/10R genotype frequency than normal female controls, with adjusted P-value < 0.05 (after adjusted for multiple testing by 1000-fold permutation tests) respectively. By MDR (Multifactor Dimensionality Reduction) analyses, the interactive effects between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 were close to the significance level (P = 0.05) in predicting the risk of co-morbidity of BPD and heroin dependence relative to normal female controls, with 1000-fold permutation testing P-value < 0.06 however > 0.05 respectively.

Conclusion

5-HTTVNTR and MAOA-LPR may have independent predictive effects on co-morbid BPD in female heroin-dependent patients; the gene-gene interactions between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 might also be involved in the etiology of this co-morbidity.