Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata
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- 作者：Ping-Chung Kuo ; Yue-Chiun Li ; Tsong-Long Hwang ; Guo-Hao Ma ; Mei-Lin Yang ; E-Jian Lee ; Tian-Shung Wu
- 关键词：Lindera ; Lauraceae ; 尾-Carboline ; Pictet&ndash ; Spengler reaction ; Superoxide anion generation
- 刊名：Tetrahedron Letters
- 出版年：1 January, 2014
- 年：2014
- 卷：55
- 期：1
- 页码：108-110
- 全文大小：377 K
文摘
Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.