Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells
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- 作者：Chongshan Dai ; Bin Li ; Yan Zhou ; Daowen Li ; Shen Zhang ; Hui Li ; Xilong Xiao ; xiaoxl@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shusheng Tang ; tssfj@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Curcumin ; Quinocetone ; Apoptosis ; Inflammatory response ; Nrf2/HO-1 pathway ; NF-kB pathway
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：52-63
- 全文大小：3571 K
文摘
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Mitochondrial apoptotic pathway and inflammatory response particulate in QCT induced cell death in L02 cell.
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Curcumin could effectively inhibit QCT induced iNOS/NO mediated inflammation via the inhibition of NF-kB pathway.
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Curcumin could effectively inhibit QCT induced mitochondrial apoptotic pathway via the activation of Nrf2/HO-1pathway.
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These foundings provide the important information for preventing QdNOs family members-induced cytotoxicity and apoptosis.