Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction
详细信息 查看全文
- 作者：Daowen Li ; Chongshan Dai ; Yan Zhou ; Xiayun Yang ; Kena Zhao ; Xilong Xiao ; Shusheng Tang ; tssfj@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Olaquindox ; GADD45a ; Apoptosis ; Mitochondrial dysfunction ; ROS
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：140-146
- 全文大小：2114 K
文摘
- •
The cytotoxic effect of olaquindox in HepG2 cells was investigated.
- •
Olaquindox-induced apoptosis involved the GADD45a expression in HepG2 cells.
- •
Knockdown of GADD45 enhanced olaquindox-induced cell death and apoptosis.
- •
Knockdown of GADD45 enhanced olaquindox-induced mitochondrial dysfunction.