RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression
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- 作者：Jie Qiua ; 1 ; Wenwei Zhangb ; 1 ; Qingsheng Xiac ; QingshengXiaqsk@163.com" class="auth_mail" title="E-mail the corresponding author ; Fuxue Liuc ; Li Lid ; Shuwei Zhaod ; Xian Gaoc ; Chuanshan Zanga ; Ruifeng Gea ; Yan Suna
- 关键词：Papillary thyroid carcinoma ; RNA-sequencing ; Differentially expressed genes ; Enrichment analysis ; ECM degradation ; Cell cycle
- 刊名：Experimental and Molecular Pathology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：100
- 期：1
- 页码：151-159
- 全文大小：1514 K
文摘
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A set of 936 differentially expressed genes (DEGs) was identified.
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RRM2 were the hub node in protein-protein interaction (PPI) network and module 3.
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Several collagens were both the hub nodes in PPI network and module 5.
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ECM degradation and cell cycle pathways were pronounced for the DEGs.
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PLAU, PSG1 and EGR2 had higher transcriptional activity in PTC than control.