Dual ultrasonic-assisted dispersive liquid-liquid microextraction coupled with microwave-assisted derivatization for simultaneous determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol by ultra high performance liquid chromatography-tandem mass spectrometry
详细信息 查看全文
- 作者：Xian-En Zhaoa ; b ; c ; xianenzhao@163.com" class="auth_mail" title="E-mail the corresponding author ; Tao Lva ; d ; Shuyun Zhua ; Fei Qua ; Guang Chena ; Yongrui Hea ; Na Weia ; Guoliang Lia ; Lian Xiaa ; Zhiwei Suna ; Shijuan Zhanga ; Jinmao Youa ; jmyou6304@163.com" class="auth_mail" title="E-mail the corresponding author ; Shu Liub ; Zhiqiang Liub ; Jing Sunc ; Shuying Liub
- 关键词：Dispersive liquid&ndash ; liquid microextraction ; Microwave-assisted derivatization ; Mass spectrometry sensitization ; 20(S)-protopanaxadiol ; 20(S)-protopanaxatriol ; Pharmacokinetics
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：1437
- 期：Complete
- 页码：49-57
- 全文大小：3073 K
文摘
- •
A new low toxic dual-UADLLME coupled with microwave-assisted derivatization was proposed.
- •
4′-Carboxy-substituted rosamine was firstly used as derivatization reagent.
- •
Simultaneous determination of PPD and PPT in rat plasma was achieved by UHPLC–MS/MS.
- •
This method was successfully applied to pharmacokinetics study.