Single session of high-intensity focused ultrasound therapy for the management of organ-confined prostate cancer: A single-institute experience

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• 作者：Yu-Cing Juho ; Sheng-Tang Wu ; Tai-Lung Cha ; Guang-Huan Sun ; Dah-Shyong Yu ; Chien-Chang Kao ; ^{guman2011@gmail.com}
• 关键词：high-intensity focused ultrasound ; localized ; nadir ; prostate cancer ; prostate-specific antigen
• 刊名：Urological Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：27
• 期：4
• 页码：226-229
• 全文大小：271 K
• 卷排序：27

文摘

The aim of this study was to evaluate the therapeutic response and complications of high-intensity focused ultrasound for patients with localized prostate cancer.Materials and MethodsWe evaluated the clinical outcomes of 29 patients who received high-intensity focused ultrasound as first-line treatment for localized prostate cancer at our hospital from October 2010 to March 2016. Biochemical recurrence was defined, according to the Stuttgart definition of biochemical failure, as the prostate-specific antigen nadir plus 1.2 ng/mL. Prostate-specific antigen levels and complications were recorded during regular follow-up.ResultsThe mean follow-up period was 24.6 months. Six patients experienced biochemical recurrence (20.68%). Disease progression was noted in six patients (20.68%), and salvage therapy was performed in these patients. The 24.6-month cancer-specific survival rate was 100%. No severe complications were reported.ConclusionHigh-intensity focused ultrasound is an alternative therapy for patients with localized prostate cancer. In combination with preceding transurethral resection of the prostate, this treatment shows promise in disease control with a low complication rate in short-term follow-up.