New findings for dentin sialophosphoprotein studies: Applications of purified odontoblast-like cells derived from stem cells

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• 作者：Nobuaki Ozeki^a ; ^{ozeki@g.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Naoko Hase^a ; Makio Mogi^b ; Kazuhiko Nakata^a
• 关键词：Dentin sialophosphoprotein ; Embryonic stem cells ; Induced pluripotent stem cells ; Human skeletal muscle stem cells ; Odontoblasts
• 刊名：Journal of Oral Biosciences
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：58
• 期：4
• 页码：128-133
• 全文大小：901 K

文摘

The biological events in dentin–pulpf-complex cells have been actively investigated for decades, but the regulation of dentin formation under both physiological and pathological conditions is still unclear. One reason for the limited knowledge of factors that affect dentin formation is the lack of proper in vitro models.

Highlight

This review summarizes in vitro experiments performed by our group and others. We present the current state of progress made in the field of stem-cell-based odontoblastic differentiation including the mechanism, and the possibility for clinical use of stem cells.

Conclusion

Mouse embryonic stem cells, mouse induced pluripotent stem cells, and α7⁺ human skeletal muscle stem cells can differentiate into odontoblast-like cells without an epithelial–mesenchymal transition, and are characterized by the signaling cascade underpinning odontoblastic differentiation, which may be useful for tooth regeneration and dentin sialophosphoprotein (DSPP) studies.