The prebiotics 3鈥睸ialyllactose and 6鈥睸ialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis
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- 作者：Andrew J. Tarra ; b ; andrew.tarr@tufts.edu" class="auth_mail" title="E-mail the corresponding author ; Jeffrey D. Galleya ; b ; Sydney E. Fishera ; b ; Maciej Chichlowskic ; Brian M. Bergc ; d ; Michael T. Baileya ; b ; e ; f ; michael.bailey2@nationwidechildrens.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gut&ndash ; brain axis ; Microbiota ; Anxiety-like behavior ; Human milk oligosaccharides ; Sialyllactose ; Hippocampus ; Neurogenesis ; Doublecortin ; Prebiotic
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：50
- 期：Complete
- 页码：166-177
- 全文大小：1346 K
文摘
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Stress impacted the gut microbiota, anxiety-like behavior, and hippocampal neurons.
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Prebiotic 3′Sialyllactose (SL) or 6′SL diminished stress effects on gut microbiota.
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Stress did not induce anxiety-like behavior in mice given 3′SL or 6′SL.
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Stress did not reduce immature hippocampal neurons in mice given 3′SL or 6′SL.
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Maintaining the gut–brain axis with diet can diminish behavioral stress effects.