Biomechanics and biorheology of red blood cells in sickle cell anemia

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• 作者：Xuejin Li^a ; ^{Xuejin_Li@brown.edu} ; Ming Dao^b ; George Lykotrafitis^c ; ^d ; George Em Karniadakis^a ; ^{George_Karniadakis@brown.edu}
• 关键词：Sickle cell disease ; Erythrocyte ; Biomechanics ; Biorheology ; Adhesion
• 刊名：Journal of Biomechanics
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：34-41
• 全文大小：3444 K
• 卷排序：50

文摘

Sickle cell anemia (SCA) is an inherited blood disorder that causes painful crises due to vaso-occlusion of small blood vessels. The primary cause of the clinical phenotype of SCA is the intracellular polymerization of sickle hemoglobin resulting in sickling of red blood cells (RBCs) in deoxygenated conditions. In this review, we discuss the biomechanical and biorheological characteristics of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology and pathogenesis of SCA. Additionally, we highlight the adhesive heterogeneity of RBCs in SCA and their specific contribution to vaso-occlusive crisis.