Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats
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- 作者：José ; Javier Reyes-Lagosa ; Martin Hadamitzkyb ; Miguel Á ; ngel Peñ ; a-Castilloa ; Juan Carlos Echeverrí ; aa ; Katharina Bö ; scheb ; Laura Lü ; ckemannb ; Manfred Schedlowskib ; Gustavo Pacheco-Ló ; pezc ; d ; g.pacheco@correo.ler.uam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heart rate variability ; Sickness behavior ; Autonomic activity ; Anti-inflammatory cholinergic pathway ; Oxytocin ; LPS
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：165
- 期：Complete
- 页码：223-230
- 全文大小：1075 K
文摘
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We studied heart rate fluctuations (HRF) during endotoxemia in a rodent model.
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Endotoxemia produces lethargy, tachycardia, more regular and anticorrelated HRF.
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A single dose of exogenous oxytocin does not modify by itself the HRF.
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Oxytocin reduces lethargy, heart rate and anticorrelation in HRF during endotoxemia.
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Oxytocin moderates the magnitude and duration of the LPS-induced hyperthermia.