Prevention and management of glucocorticoid-induced side effects: A comprehensive review: A review of glucocorticoid pharmacology and bone health

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• 作者：Avrom Caplan ; MD^a ; ^c ; Nicole Fett ; MD^b ; Misha Rosenbach ; MD^a ; ^c ; Victoria P. Werth ; MD^a ; ^c ; Robert G. Micheletti ; MD^a ; ^c ; ^{robert.micheletti@uphs.upenn.edu}
• 关键词：glucocorticoids ; medication monitoring ; osteonecrosis ; osteoporosis ; pharmacology ; side effects ; steroids
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：1
• 页码：1-9
• 全文大小：369 K
• 卷排序：76

文摘

Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple side effects can produce significant morbidity for patients. The objective of this review is to discuss these side effects while addressing 3 questions: 1) What dose and duration of glucocorticoid therapy should prompt concern for individual side effects?; 2) How should clinicians counsel patients about these complications?; and 3) How can these problems be prevented or managed? To accomplish these objectives, we have created a series of tables and algorithms based on a review of relevant data to guide counseling, prophylaxis, and management of 11 glucocorticoid side effects. The first article in this 4-part continuing medical education series begins with a review of glucocorticoid pharmacology followed by a discussion of bone health (ie, osteoporosis and osteonecrosis).