Analyzing habituation responses to novelty in zebrafish (Danio rerio)
详细信息 查看全文
- 作者：Keith Wong ; Marco Elegante ; Brett Bartels ; Salem Elkhayat ; David Tien ; Sudipta Roy ; Jason Goodspeed ; Chris Suciu ; Julia Tan ; Chelsea Grimes ; Am ; a Chung ; Michael Rosenberg ; Siddharth Gaikwad ; Ashley De
- 关键词：Zebrafish ; Habituation to novelty ; Drug effects ; Cognition and learning ; Anxiety ; Spatial working memory
- 刊名：Behavioural Brain Research
- 出版年：2010
- 出版时间：2 April 2010
- 年：2010
- 卷：208
- 期：2
- 页码：450-457
- 全文大小：1153 K
文摘
Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish. Analyzing the intra-session habituation to novelty further, we also show that selected anxiogenic drugs (caffeine, pentylenetetrazole), as well as stress-inducing alarm pheromone, attenuated zebrafish habituation. Some acute anxiolytic agents, such as morphine and ethanol, while predictably reducing zebrafish anxiety, had no effects on habituation. Chronic ethanol and fluoxetine treatments improved intra-session habituation in zebrafish. In general, our study parallels literature on rodent habituation responses to novelty, and reconfirms zebrafish as a promising model for cognitive neurobehavioral research.