Solution conformation of tuftsin
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- 作者：Siddiqui ; Mahtab Z. ; Sharma ; Ashwani K. ; Kumar ; Satish
- 关键词：Tuftsin ; an immunomodulator peptide ; Conformation ; Circular dichroism spectroscopy
- 刊名：International Journal of Biological Macromolecules
- 出版年：1996
- 出版时间：August, 1996
- 年：1996
- 卷：19
- 期：2
- 页码：99-102
- 全文大小：278 K
文摘
Conformation of chemically synthesized tetrapeptide tuftsin, an important immunomodulator, with the sequence Thr-Lys-Pro-Arg-OH has been studied in aqueous solution as well as in a number of organic solvents viz. trifluoroethanol (TFE), methanol and dioxane by circular dichroism (CD) spectroscopy which reveals preferential occurrence of mixture of random coil and β-turns, that has already been predicted as bioactive conformation of this peptide.