Dehydrophenylalanine analogues: conformational characterization

详细信息    查看全文

• 作者：Siddiqui ; Mahtab Z.
• 关键词：Dehydrophenylalanine peptides ; Synthesis ; Conformation ; Circular dichroism spectroscopy
• 刊名：International Journal of Biological Macromolecules
• 出版年：1999
• 出版时间：October, 1999
• 年：1999
• 卷：26
• 期：1
• 页码：17-21
• 全文大小：112 K

文摘

Few dehydrophenylalanine (ΔPhe) analogues (X-ΔPhe-Phe-Gly-X1, X=Ac-; Boc-; Z-; X1=OMe; OH; ONH₂) of virus replication inhibiting peptide (Z-D-Phe-Phe-Gly) were synthesized, and their solution conformations were investigated by ¹H NMR, UV and circular dichroism (CD) spectroscopy. Homogeneity of these analogues was also assessed by reverse phase-high performance liquid chromatography (RP-HPLC) using water–acetonitrile gradients.