Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function
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- 作者：Maria L. Balmer1 ; Eric H. Ma2 ; 3 ; Glenn R. Bantug1 ; Jasmin Grä ; hlert1 ; Simona Pfister4 ; Timo Glatter5 ; Annaï ; se Jauch6 ; Sarah Dimeloe1 ; Emma Slack7 ; Philippe Dehio1 ; Magdalena A. Krzyzaniak8 ; Carolyn G. King9 ; Anne-Valé ; rie Burgener1 ; Marco Fischer1 ; Leyla Develioglu1 ; Ré ; ka Belle1 ; Mike Recher6 ; Weldy V. Bonilla8 ; Andrew J. Macpherson10 ; Siegfried Hapfelmeier4 ; Russell G. Jones2 ; 3 ; Christoph Hess1 ; chess@uhbs.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：44
- 期：6
- 页码：1312-1324
- 全文大小：2403 K
文摘
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Serum acetate levels rapidly increase following systemic bacterial infection
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Memory CD8+ T cells take up acetate and expand their acetyl-CoA pool
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Increased acetyl-CoA levels catalyze functional activity of GAPDH by acetylation
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Augmented glycolytic flux rates boost rapid recall responses of memory CD8+ T cells