The Interleukin-1 Family: Back to the Future

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• 作者：Cecilia Garl ; a ; Charles聽A. Dinarello ; Alberto Mantovani
• 刊名：Immunity
• 出版年：12 December, 2013
• 年：2013
• 卷：39
• 期：6
• 页码：1003-1018
• 全文大小：2859 K

文摘

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1伪 and IL-1尾, IL-18, IL-33, IL-36伪, IL-36尾, IL-36纬), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37). Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb). A tight regulation via receptor antagonists, decoy receptors, and signaling inhibitors ensures a balance between amplification of innate immunity and uncontrolled inflammation. All cells of the innate immune system express and/or are affected by IL-1 family members. Moreover, IL-1 family members play a key role in the differentiation and function of polarized innate and adaptive lymphoid cells. Here we will review the key properties of IL-1 family members, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity.