Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood: A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses
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- 作者：Theresa R. Wilhelmc ; Adriano Taddeoa ; b ; Oliver Wintera ; b ; Axel Ronald Schulzd ; b ; Julia-Nora Mä ; lzerd ; Cristina Domingoe ; Robert Biesena ; Tobias Alexandera ; Andreas Thield ; Andreas Radbruchb ; Falk Hiepea ; b ; Velia Gerla ; b ; gerl@drfz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasmacytoide dendritic cell ; Siglec-1 ; Systemic lupus ; Erythematosus
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：42-51
- 全文大小：1531 K
文摘
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We identified a Siglec-1 expressing subset of pDCs in human peripheral blood.
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Siglec-1+ pDCs reveal a semi-mature and myeloid-like phenotype.
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In vitro, Siglec-1 is induced by influenza virus in Siglec-1− blood pDCs.
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Siglec-1+/Siglec-1− ratio is imbalanced in SLE and during acute immune responses.
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Increased Siglec-1+/Siglec-1− ratio correlates with disease activity in SLE.