Reduced immune response to polymeric micelles coating sialic acids

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• 作者：Masashi Ohmae^a ; ^{ohmae@peptide.polym.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Mei Kojima^a ; Kenta Mihara^a ; Yuji Yamazaki^a ; Isao Hara^b ; Eri Hara^c ; Shunsaku Kimura^a
• 关键词：Lactosome ; Accelerated blood clearance phenomenon ; Siglecs ; Sialic acid ; Nanocarriers
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：26
• 期：20
• 页码：4976-4982
• 全文大小：1840 K

文摘

Effects of sialic acid coatings on polymeric micelle consisting of poly(sarcosine)-block-poly(l-lactic acid) (Lactosome) in the aim of prevention of the accelerated blood clearance (ABC) phenomenon are studied. Two kinds of the sialic acid-presenting Lactosomes targeting the immunosuppressive receptors of Siglec-G and CD22 have been successfully prepared. Lactosome presenting 5-N-acetylneuraminic acid or 5-N-acetylneuraminyl-α(2 → 6)-galactosyl-β(1 → 4)-N-acetylglucosamine at the nanocarrier surface diminished the ABC phenomenon due to the reduction of the anti-poly(sarcosine) IgM production. Further, the sialic acid moieties could interact possibly with Siglec-E on immune cell to suppress phagocytosis of the opsonized nanocarriers.