Pathogen-associated porin turns IL-10 competent B-1a cells toward proinflammatory cytokine response
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- 作者：Amlan Kanti Ghosh ; Debolina Sinha ; Ratna Biswas ; Tapas Biswas ; shigellaporin@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：APC ; antigen-presenting cell ; DC ; dendritic cell ; LPS ; lipopolysaccharide ; MΦ ; macrophage ; PerC ; peritoneal cavity ; Siglec-G ; sialic-acid-binding immunoglobulin-like lectin ; TLR ; toll-like receptor
- 刊名：Immunobiology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：221
- 期：12
- 页码：1369-1373
- 全文大小：767 K
文摘
Shigellosis is a major problem in the developing countries causing mortality and morbidity particularly among the children. Shigella spp. harbours the epithelial cells of the human colon to infect the host and spread the disease.
We analyzed the response of B-1a cells, the major component of the mucosal immune system to porin of Shigella dysenteriae type 1. We show that porin while proliferating B-1a cells, deplete Siglec-G, the inhibitory molecule present on B-1a cells. Adjuvanticity of porin has been shown to govern innate signaling for promoting host adaptive immune response. Up-regulation of CD69 and CD40 denotes activation of the cells parallel to abrogation of Siglec-G. As a result of cell activation, porin stimulated the inflammatory cytokines of CD5+ B-1a cells, otherwise rich in IL-10. The work shows B-1a cell responses promote the immunopotentiating activity of porin.