Discovery and expression of 3 siglecs-like in Oreochromis niloticus neutrophil, and their interaction with group B streptococcal sialylated capsular polysaccharides
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- 作者：Junjian Donga ; 1 ; Yuanzheng Weia ; 1 ; Xing Yea ; b ; gzyexing@163.com" class="auth_mail" title="E-mail the corresponding author ; Chengfei Suna ; Yuanyuan Tiana ; b ; Maixin Lua ; b ; Juanjuan Dua ; b ; Zhihang Chena ; b
- 关键词：Oreochromis niloticus ; Neutrophils ; Sialic acid-binding immunoglobulin-like lectin-1/-4b/-14-like (Siglec-1/-4b/-14-like) ; Streptococcus agalactiae (Group B Streptococcus ; GBS) ; Sialylated capsular polysaccharides
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：158-169
- 全文大小：6162 K
文摘
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We cloned the OnSiglec-1/-4b/-14 gene cDNA and detailedly analysed its homology and phylogenetic.
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We examine expression of OnSiglec-1/-4b/-14 in nine tissues in untreated individuals.
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We examine tissue expression changes of OnSiglec-1/-4b/-14 gene post GBS infection.
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We confirmed that OnSiglec-1/-4b/-14 have high binding activity with GBS and sialic acid polysaccharides by flow cytometry, ELISA and adhesion assays.