Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse

详细信息    查看全文

• 作者：Amit K. Patel^a ; Kevin K. Park^b ; Abigail S. Hackam^a ; ^{ahackam@med.miami.edu}
• 关键词：ANOVA ; Analysis of Variance ; CTB ; cholera toxin β subunit ; GCC ; ganglion cell complex ; IPL ; inner plexiform layer ; ONC ; optic nerve crush ; PERG ; pattern electroretinography ; PVDF ; polyvinylidene fluoride ; RGCs ; retinal ganglion cells ; TCF/Lef ; T-cell factor/lymphoid enhancer-binding factor
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：372-383
• 全文大小：1814 K
• 卷排序：343

文摘

Activation of the canonical Wnt/β-catenin signaling pathway led to axonal regeneration in a mouse optic nerve injury model. Wnt signaling was active in retinal ganglion cells (RGCs). Wnt3a also led to increased RGC survival after injury. The transcription factor Stat3 contributes to Wnt3a-induced axonal regeneration and RGC survival. These findings demonstrate a novel role for retinal Wnt signaling in axonal regrowth.