K040706 attenuated DSS-induced colitis severity and epithelial injury. K040706 suppressed the DSS-induced expression of pro-inflammatory mediators. K040706 downregulated the DSS-induced activation of TLR4/NF-κB/STAT3 signaling. K040706 improved the intestinal microbiota composition. K040706 has potential as a treatment option for inflammatory bowel disease.